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The Impact of Antipsychotic Drugs on Long-term Care, Nursing Home Admission, and Death in Dementia Patients
| Content Provider | Semantic Scholar |
|---|---|
| Author | Nerius, Michael Johnell, Kristina Garcia-Ptacek, Sara Eriksdotter, Maria Haenisch, Britta Doblhammer, Gabriele |
| Copyright Year | 2018 |
| Abstract | Background Behavioral and psychological symptoms of dementia are commonly treated with antipsychotic drugs (APDs), which have been associated with adverse health effects. We examine the effect of APDs on long-term care (LTC), nursing home (NH) admission, and death of dementia patients. Methods We used health claims data of the largest German health insurer from 2004 to 2010 and followed newly-diagnosed dementia patients aged 60 years and older into LTC, NH, and until death. Cox proportional hazards models were estimated to explore whether the risk of these outcomes differed between patients receiving haloperidol, melperone, risperidone, or quetiapine. Results In a cohort of 6,930 dementia patients who were initially free of LTC dependency, APD users generally faced a twofold increased risk of LTC relative to nonusers. Quetiapine was the exception, showing a comparatively lower risk (HR = 1.64; CI = 1.35-1.98). Among 9,950 dementia patients initially living in private homes, the risk of moving into a NH was generally increased by about 50% among APD users relative to nonusers. Risk of death (N = 10,921) was significantly higher for haloperidol-, melperone-, and risperidone- but not for quetiapine users (HR = 0.91; CI = 0.78-1.08). The excess mortality associated with haloperidol and melperone was greater among patients living in private households. Conclusions In our study, APDs appeared to accelerate adverse health outcomes in German dementia patients. Differentiating between the effect of antipsychotic drug use among dementia patients residing in private households and in NHs, we found that excess mortality for haloperidol and melperone users was higher in private settings. |
| Starting Page | 1396 |
| Ending Page | 1402 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://watermark.silverchair.com/glx239.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAdUwggHRBgkqhkiG9w0BBwagggHCMIIBvgIBADCCAbcGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQM9bsKiBxppM6lIeXmAgEQgIIBiAZ_w6sE4qZdLJmtWKOZyKsKXehsZkhyWGKv_etd1E5nQdqQUIEzHcZLAEdoaPJqDhqayXl07GvSp_0l0wetrVb5xPhPRbMYb5PM1zukTM1kE8JIXjXnCDNbhROWAYLp5iyVkXJ5X6-BVE_FzZ_m0U44WpaWyFQCeXs-Fl0fBMGv05GueB-ot-YeGeZtFJfWB0KUc_2rSnxLY4umk4sKBoTxyW5XA8fABLA1fPlhsmeSst5sWYnqsOmqflCNxqthvOpOm0VqDA3zH_iowowrbBrL0v5et3DvxqDODr1XP7TfZ2JJcAtqrJn4AWIa-TBqHkSUnHFdZTHV_lDNO1N1fss6i3YTawxEjbrITaR_yd0DsIBIuLdlaPikmK6dEzDG-1D05WUTJGqnPyciTRtI5PP2r8DLQi92Q8cNj1j9QWgQLE_vIek2xcDiDS_WSHVyO2MD8p2WAl5J7VB4iPNT6y92BTTCOdu2ln5NOTaJPVY2ldZRrjnTrNU3Vi1cxxWsANrCmq8svg0Y |
| PubMed reference number | 29228107v1 |
| Alternate Webpage(s) | https://doi.org/10.1093/gerona/glx239 |
| DOI | 10.1093/gerona/glx239 |
| Journal | The journals of gerontology. Series A, Biological sciences and medical sciences |
| Volume Number | 73 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acclimatization Antipsychotic Agents Appetite Depressants Beer Biological Science Disciplines Breast Feeding Cessation of life Discipline of Nursing Geriatrics Haloperidol Insurance Carriers Journal Largest Medicine Nursing Homes Patients Presenile dementia Risperidone emotional dependency long-term care metylperon pamidronate quetiapine |
| Content Type | Text |
| Resource Type | Article |
