NDLI: Antifungal effect of Atorvastatin against Candida species in comparison to Fluconazole and Nystatin

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Antifungal effect of Atorvastatin against Candida species in comparison to Fluconazole and Nystatin

Content Provider	Semantic Scholar
Author	Esfahani, Ava Nasr Golestannejad, Zahra Khozeimeh, Faezeh Dehghan, Parvin Maheronnaghsh, Mehrnoosh Zarei, Zahra
Copyright Year	2019
Abstract	Background and aims Atorvastatin is a plasma cholesterol-lowering drug which applies antifungal effects by inhibiting the production of yeast cell wall ergostrol. The aim of present study was to investigate in-vitro susceptibility of candida species to atorvastatin, in comparison to nystatin and fluconazole. Methods Minimum inhibitory concentrations (MIC) and minimum fungicidal concentrations (MFC) were determined using serial dilution. Candida strains isolated from 35 patients receiving cancer chemotherapy in Isfahan, Seyyed-al-Shohada Hospital and analyzed by Kruskal-Wallis and Mann Whitney statistical methods. Results Candida isolates included 5 strains, C. albicans, C. glabrata, C. kefyr, C. stellatoidea and C. krusei. All five strains appeared to be resistant to nystatin and fluconazole but sensitive to atorvastatin with no statistically significant difference. The MFC of atorvastatin was significantly lower in comparison to both nystatin and fluconazole for all five strains (p value<0.05). There was no significant difference between the MFCs of 5 strains for fluconazole and atorvastatin. However, MFC of nystatin differed significantly for C. albicans and C. kefyr (p=0.007). Conclusion The results showed that all strains were sensitive to atorvastatin and resistant to nystatin and fluconazole. Atorvastatin MIC for C. albicans, C. krusei and C. stellatoidea was equivalent to its serum level used to treat hyperlipidemia and was above such level for both C. glabrata and C. kefyr.
Starting Page	368
Ending Page	373
Page Count	6
File Format	PDF HTM / HTML
DOI	10.15386/mpr-1209
PubMed reference number	31750437
Journal	Medline
Volume Number	92
Alternate Webpage(s)	https://medpharmareports.com/index.php/mpr/article/download/1209/2501
Alternate Webpage(s)	https://doi.org/10.15386/mpr-1209
Journal	Medicine and pharmacy reports
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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