Screening Various Plant and Fungal Extracts Against Clostridium perfringens for Antimicrobial Activity

Content Provider	Semantic Scholar
Author	Larson, Thomas R.
Copyright Year	2007
Abstract	Clostridium is an anaerobic, endospore forming Gram-positive bacillus genus containing many important pathogenic species, including Clostridium difficile and Clostridium perfringens. Both of these pathogenic species have been implicated as the causative agents of serious gastrointestinal tract infections. Recently, there has been an emergence of antimicrobial drug resistant Clostridium species. Because of these concerns, a new drug is warranted. There is an ecological rationale that antimicrobial products could be synthesized in fungi and plants to ward of pathogens like Clostridium. To explore this further, plant and fungal specimens have been collected and a solvent extraction procedure has been performed. Crude extracts taken from various plants and fungal fruiting bodies have been screened against C. perfringens for evidence of antimicrobial activity. A total of 238 extracts from various fungi and plant species have been screened against C. perfringens. Of these, 25 showed antimicrobial activity against C. perfringens. Furthermore, a total of 17 fungal extracts demonstrated hemolytic activity and antimicrobial activity against C. perfringens while 8 extracts generated no hemolytic activity while showing antimicrobial activity. Further purification and analysis is currently being performed on promising crude extracts in order to unearth any potential novel antimicrobial agents.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.uwlax.edu/urc/JUR-online/PDF/2007/larson.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article