Loading...
Please wait, while we are loading the content...
Similar Documents
I'm Losing Cell Viability and Function at Different Points in My Process, and I Don't Know Why!
| Content Provider | Semantic Scholar |
|---|---|
| Author | Mathew, Aby J. |
| Copyright Year | 2010 |
| Abstract | June 2010 Development of cell and tissue therapies presents bottlenecks in manufacturing process development and scale-up as commercial and academic groups move from small-scale research and development (R&D) to more complex logistics. Often, the simplicity of maintaining cell yield, viability, and function in a laboratory setting cannot be replicated when source tissue and final therapeutic products are subjected to the extended distances and times of actual clinical delivery. These bottleneck issues have a number of causes. One specific and common cause is suboptimal biopreservation workflow processes and practices. At BioLife Solutions, we often address this particular issue in consultations with current and prospective customers, where we’ve heard the title of this article from a number of people. The following case study — a hypothetical amalgam drawn from our experiences — highlights various biopreservation workflow process optimization steps that can extend stability. This may improve postpreservation viability and functional yield of cellular source materials and final cell-based products. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://bioprocessintl.com/wp-content/uploads/2014/05/BPI_A_100806AR06_O_98059a.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
