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Antidiabetic Activity of Leaves of Talinum Portulacifolium (forssk) in Alloxan - Induced Diabetic Rats
| Content Provider | Semantic Scholar |
|---|---|
| Author | Rao, Tentu. Nageswara Lakshmi, Sabapathi Mohana Sree Sainath Nagar Rangam, A. |
| Copyright Year | 2007 |
| Abstract | Summary The present study was under taken to examine the effect of methanolic extract of Talinum portulacifolium (METP) leaves for its anti-hyperglycemic activity against alloxan induced diabetes. The anti-hyperglycemic effect of METP was evaluated in alloxan induced diabetic rats by monitoring its effect on blood glucose, serum lipid profiles (triglycerides and total cholesterol), liver glycogen, malondialdehyde and reduced glutathione (GSH) levels. The rats, pretreated with METP (400 mg/kg p.o) improved oral glucose tolerance compare to glucose fed rats. After oral administration of METP in diabetic rats for 15 days, the blood glucose, lipid profile and malondialdehyde has significantly decreased, while liver glycogen and reduced glutathione were increased significantly. Histopathological studies of the pancreas of these animals showed comparable regeneration by METP, which were earlier necrosed by alloxan. Antihyperglycemic activity of METP was compared with oral hypoglycemic agent, glibenclamide. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://pharmacologyonline.silae.it/files/archives/2007/vol2/40_NageswaraRao.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |