NDLI: The protective effect of vitamin C on Azoxymethane-induced oxidative stress in colon of mice.

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The protective effect of vitamin C on Azoxymethane-induced oxidative stress in colon of mice.

Content Provider	Semantic Scholar
Author	Karabulut, Aysun Bay Özgör, Dinçer Ara, Cengiz Diıriıcan, A. Kahraman, Levent Yaman, Hülya
Copyright Year	2009
Abstract	Purpose: The Azoxymethane model for colon carcinogenesis is often used to study on the initiation and promotion stages of colon carcinogenesis in mice. Our aim in this study was to evaluate the effects of vitamin C on levels of oxidative stress parameters in azoxymethane induced colonic oxidative stress in mice. Material and Methods: In this purpose thirty Swiss albino mice (weighing 31.49±3.1 g), aging 12 weeks were randomly divided into three groups of ten each. Animals of group I and II were treated with weekly doses of subcutaneous 5 mg/kg azoxymethane for 7 weeks, whereas, the mice in group II were further treated with 500 mg/kg vitamin C administered intraperitoneally during the same period. Group III served as the control group. Results: In the vitamin C treated mice, levels of MDA and NO were significantly lower than those of azoxymethane only group (p=0.031, p<0.001). The levels of GSH in the vitamin C treated mice were significantly higher than that of azoxymethane only group (p=0.004). Conclusion: The present study demonstrates that intraperitoneal administration of vitamin C reduces azoxymethane induced oxidative stress in colon of mice.
Starting Page	305
Ending Page	309
Page Count	5
File Format	PDF HTM / HTML
Volume Number	31
Alternate Webpage(s)	http://erciyesmedj.com/sayilar/234/buyuk/pdf_emj_3941.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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