Experimental study of airway pressure release ventilation in the treatment of acute respiratory distress syndrome

Content Provider	Semantic Scholar
Author	Han, Guan-jie Li, Jia-qiong Pan, Cui-gai Sun, Jing-Xi Shi, Zai-xiang Xu, Ji-yuan Li, Mao-qin
Copyright Year	2017
Abstract	Airway pressure release ventilation (APRV) is a ventilator mode which has demonstrated potential benefits in acute respiratory distress syndrome (ARDS) patients. We therefore sought to compare relevant pulmonary data and safety outcomes of this mode to the conventional ventilation and sustained inflation. Canines admitted after intravenous injection of oleic acid requiring mechanical ventilation were randomly divided into 3 groups (n=6), namely conventional ventilation group, low tidal volume ventilation with recruitment group (LTV+SI) and APRV group. The changes of oxygenation, ventilation, airway pressure, inflammatory reaction and hemodynamics at the basic state were observed at 0, 1, 2 and 4 h during the experiment. The levels of PaO2/FiO2 in APRV group were higher than LTV+SI group at 2 and 4 h (P<0.05). In APRV group, the PCO2 levels at 1, 2 and 4 h is much lower than LTV+SI group (P<0.05). Outcome variables showed no differences between APRV, LVT+SI and conventional mechanical ventilation for plateau airway pressure (24±1 vs. 29±3 vs. 25±4), mean arterial pressure (92.9±16.5 vs. 85.8±21.4 vs. 88.7±24.4), cardiac index (4.3±1.7 vs. 3.5±1.9 vs. 3.4±2.1), ERO2 (13.4±10.3 vs. 16.1±6.8 vs. 17.6±9.1), lac (2.5±1.7 vs. 3.1±1.6 vs. 3.9±1.9), tumor necrosis factor (TNF)-α (132±11 vs. 140±6 vs. 195±13) and matrix metalloproteinase (MMP)-9. For canines sustaining acute respiratory distress syndrome requiring mechanical ventilation, APRV can significantly improve oxygenation and keep hemodynamic stability compared with LTV+SI. The results of TNF-α and MMP-9 suggest that APRV could be as protective for ARDS as LTV with recruitment group.
Starting Page	1941
Ending Page	1946
Page Count	6
File Format	PDF HTM / HTML
PubMed reference number	28962107v1
Alternate Webpage(s)	https://doi.org/10.3892/etm.2017.4718
DOI	10.3892/etm.2017.4718
Journal	Experimental and therapeutic medicine
Volume Number	14
Language	English
Access Restriction	Open
Subject Keyword	Airway Pressure Release Ventilation Auditory recruitment Canis familiaris Cell Respiration Hemodynamics Matrix Metalloproteinases Mechanical ventilation Metalloproteases Neoplasms Oleic Acid Partial Pressure Arterial Oxygen to Fraction Inspired Oxygen Ratio Measurement Patients Pelvic Inflammatory Disease Respiratory Distress Syndrome, Adult Tumor Necrosis Factor-alpha Ventilator - respiratory equipment benefit
Content Type	Text
Resource Type	Article