NDLI: 18F-FDG PET/CT for early prediction of response to neoadjuvant chemotherapy in breast cancer

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18F-FDG PET/CT for early prediction of response to neoadjuvant chemotherapy in breast cancer

Content Provider	Semantic Scholar
Author	Duch, Joan Fuster, David Muñoz, Montserrat Fernández, Pedro Luis Sánchez Paredes, Pilar Fontanillas, Montserrat Guzmán, Flavia Rubí, Sebastiá Lomeña, Francisco Pons, Françesca
Copyright Year	2009
Abstract	PurposeThe aim of this study was to prospectively evaluate 18F-FDG PET/CT in predicting response to neoadjuvant chemotherapy in large primary breast cancer.MethodsFifty consecutive patients underwent PET/CT at baseline and after the second cycle. Baseline MRI was performed to establish tumour size. All findings were confirmed by histopathological analysis. Changes in maximum standardized uptake value (SUVmax) between baseline study and after two cycles of neoadjuvant chemotherapy (epirubicin + cyclophosphamide + taxanes) were compared using response evaluation criteria in solid tumours (RECIST) criteria and the Miller and Payne (M&P) scale.ResultsThe mean tumour size was 4.3 ± 1.4 cm. Forty patients were considered responders and ten as non-responders. SUVmax changes in patients with good prognosis (M&P grades 4–5) were higher than in patients with bad prognosis (M&P grades 1–3) (p = 0.025). SUVmax changes between responders and non-responders following RECIST criteria were also statistically significant (p = 0.0028). A cut-off ΔSUV value of 40% differentiates both groups, with a sensitivity of 77% and a specificity of 80%.Conclusion18F-FDG PET/CT can predict response to neoadjuvant chemotherapy at an early stage.
Starting Page	1551
Ending Page	1557
Page Count	7
File Format	PDF HTM / HTML
DOI	10.1007/s00259-009-1116-y
Alternate Webpage(s)	http://nuclear.xqhospital.com.cn:8050/uploadfile/2009/10/19/20091019024431.pdf
PubMed reference number	19326117
Alternate Webpage(s)	https://doi.org/10.1007/s00259-009-1116-y
Journal	Medline
Volume Number	36
Journal	European Journal of Nuclear Medicine and Molecular Imaging
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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