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Sodium transport parameters in erythrocytes of patients with primary aldosteronism.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Smith, J. J. B. Wade, Michael W. Fineberg, Naomi Weinberger, Myron H. |
| Copyright Year | 1988 |
| Abstract | Primary aldosteronism is an uncommon cause of hypertension but one of particular interest because of its distinctive pathophysiological mechanism of blood pressure elevation. Aldosterone has been associated with increased Na+,K+-adenosine triphosphatase (ATPase) activity, but there is controversy over which sodium transport parameters are responsible for this increase. We measured intracellular sodium, ouabain-sensitive and ouabain-insensitive sodium efflux, and the number of Na+,K+-ATPase sites of washed erythrocytes, as well as Na+-Li+ countertransport and the Li+-K+ cotransport rate constant of lithium-loaded red blood cells (RBCs) in six patients with primary aldosteronism and in 50 normal subjects. Ouabain-sensitive sodium efflux was significantly (p less than 0.001) higher for the primary aldosteronism patients than for normal subjects (1.85 +/- 0.29 vs 1.51 +/- 0.21 mmol/L RBC/hr) even though the intracellular sodium concentration (7.2 +/- 1.5 vs 6.7 +/- 1.9 mM) and the number of the Na+,K+-ATPase sites per RBC (331 +/- 52 vs 385 +/- 97) were not increased. The elevated sodium efflux appeared to be due to a significant (p less than 0.001) increase in the rate constant (1.60 +/- 0.12 x 10(-15) vs 1.28 +/- 0.15 x 10(-15) mmol/site/hr) of the ouabain-sensitive sodium efflux. The rate constant decreased significantly (p less than 0.01) after treatment. |
| Starting Page | 512 |
| Ending Page | 514 |
| Page Count | 3 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://hyper.ahajournals.org/content/hypertensionaha/11/2/141.full.pdf |
| Alternate Webpage(s) | http://hyper.ahajournals.org/content/hypertensionaha/11/2/141.full.pdf?download=true |
| PubMed reference number | 2449394v1 |
| Volume Number | 11 |
| Issue Number | 2 |
| Journal | Hypertension |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Addison Disease Aldosterone Conn Syndrome Hyperaldosteronism Hypertensive disease Lithium Ouabain Patients Red Blood Cell Count measurement sodium ion transport |
| Content Type | Text |
| Resource Type | Article |
