NDLI: Preconcentration and Determination of Psychotropic Drugs in Urine Samples by Ion Mobility Spectrometry with Electrospray Ionization Coupling On-Line Single-Drop Liquid-Liquid-Liquid Microextraction

Content Provider	Semantic Scholar
Author	Li, Shuqin
Copyright Year	2019
Abstract	Amethod for analysis of psychotropic drugs in urine is investigated using a novel single-drop liquid-liquid-liquid microextraction (SDLLLME) apparatus as an electrospray emitter in ion mobility spectrometry (IMS). In this method, ketamine and pethidine are back-extracted into the acceptor phase (water and methanol) from the water and methanol immiscible organic phase. Sensitivity of extraction is improved as it does not require further methanol-adding procedure. Factors affecting the extraction of psychotropic drugs are characterized, including organic solvent type, extraction time, and concentration of NaOH/Ac in the donor/ acceptor phase. +e best extraction sensitivity is obtained with 600 μL dodecane as the organic phase, 30 minutes extraction time, and 10mL donor phase with 0.01M sodium hydroxide (NaOH) and 3 μL acceptor phase with 0.5M acetic acid (Ac). Using this method, the two analytes can be extracted and analyzed simultaneously, showing this method is valuable for field application.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://downloads.hindawi.com/journals/jamc/2019/8561801.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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