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Treated depression in adolescents: predictors of outcome at 28 weeks.

Content Provider	Semantic Scholar
Author	Wilkinson, Paul Oliver Dubicka, Bernadka W. Kelvin, Raphael G. Roberts, Chris S. J. Goodyer, Ian M.
Copyright Year	2009
Abstract	BACKGROUND There is great heterogeneity of clinical presentation and outcome in paediatric depression. AIMS To identify which clinical and environmental risk factors at baseline and during treatment predicted major depression at 28-week follow-up in a sample of adolescents with depression. METHOD One hundred and ninety-two British adolescents with unipolar major depression were enrolled in a randomised controlled trial (the Adolescent Depression Antidepressants and Psychotherapy Trial, ADAPT). Participants were treated for 28 weeks with routine psychosocial care and selective serotonin reuptake inhibitors (SSRIs), with half also receiving cognitive-behavioural therapy (CBT). Full clinical and demographic assessment was carried out at baseline and 28 weeks. RESULTS Depression at 28 weeks was predicted by the additive effects of severity, obsessive-compulsive disorder and suicidal ideation at entry together with presence of at least one disappointing life event over the follow-up period. CONCLUSIONS Clinicians should assess for severity, suicidality and comorbid obsessive-compulsive disorder at presentation and should monitor closely for subsequent life events during treatment.
Starting Page	272
Ending Page	279
Page Count	8
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://bjp.rcpsych.org/content/bjprcpsych/194/4/334.full.pdf
Alternate Webpage(s)	https://www.cambridge.org/core/services/aop-cambridge-core/content/view/A0426E4E366067AEF1A1FC384E3524EA/S0007125000249428a.pdf/treated_depression_in_adolescents_predictors_of_outcome_at_28_weeks.pdf
PubMed reference number	19336785v1
Alternate Webpage(s)	https://doi.org/10.1192/bjp.bp.108.052381
DOI	10.1192/bjp.bp.108.052381
Journal	The British journal of psychiatry : the journal of mental science
Volume Number	194
Issue Number	4
Language	English
Access Restriction	Open
Subject Keyword	Adolescent (age group) Antidepressive Agents Cognition Disorders Compulsive Personality Disorder Major Depressive Disorder Obsessive-Compulsive Disorder Selective Serotonin Reuptake Inhibitors Serotonin Uptake Inhibitors
Content Type	Text
Resource Type	Article

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