Synchronized population oscillation of excitatory synaptic potentials dependent of calcium-induced calcium release in rat neocortex layer II/III neurons

Content Provider	Semantic Scholar
Author	Yoshimura, H. Sugai, Tokio Onoda, Norihiko Segami, Natsuki Kato, Nobukatsu
Copyright Year	2001
Abstract	We examined the roles played by calcium-induced calcium release from ryanodine-sensitive calcium stores in induction of neocortical membrane potential oscillation by using caffeine, an agonist of ryanodine receptors. Intracellular recordings were made from neurons in layer II/III of rat visual cortex slices in a caffeine-containing medium. White matter stimulation initially evoked monophasic synaptic potentials. As low-frequency stimulation continued for over 10 min, an oscillating synaptic potential gradually became evoked, in which a paroxysmal depolarization shift was followed by a 8-10-Hz train of several depolarizing wavelets. This oscillating potential was not induced in a medium containing no caffeine with 2 or 0.5 mM [Mg2+](o). Under blockade of N-methyl-D-aspartate receptors, induction of this oscillating potential failed even with caffeine application. Experiments with the calcium store depletor, thapsigargin, revealed that this oscillating potential is induced in a manner dependent on intracellular calcium release. Dual intracellular recordings revealed that the oscillation was synchronized in pairs of layer II/III neurons. The oscillating potential was detectable by field potential recordings also, suggesting that the present oscillation seems to reflect a network property.
Starting Page	94
Ending Page	100
Page Count	7
File Format	PDF HTM / HTML
DOI	10.1016/S0006-8993(01)02832-3
PubMed reference number	11578624
Journal	Medline
Volume Number	915
Alternate Webpage(s)	http://www.cnbc.cmu.edu/~samondjm/papers/Yoshimuraetal2001.pdf
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0006899301028323
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0006899301028323?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/S0006-8993%2801%2902832-3
Journal	Brain Research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article