Pharmacodynamic evaluation of proniosomal transdermal therapeutic gel containing celecoxib

Content Provider	Semantic Scholar
Author	Alam, Mohammad Intakhab Baboota, Sanjula Kohli, Kanchan Ali, Javed Ahuja, Alka Nagar, Hamdard
Copyright Year	2010
Abstract	A low dose proniosomal gel containing celecoxib was developed for the treatment of osteoarthritis. All the prepared formulations were subjected to physicochemical evaluations and anti-inflammatory studies. The entrapment was > 90%. The vesicle shape was determined with the help of transmission electron microscopy. The vesicle size, size- distribution, and polydispersity studies were performed using photon correlation spectroscopy. Anti-inflammatory studies were performed using the rat hind-paw oedema induced by carrageenan (1% w/v). The selected proniosomal gel (N1LE3) produced 100% inhibition of paw oedema in rats up to 8 h after carrageenan injection. It produced 95% and 92% inhibition after 12 h and 24 h, respectively. These results indicate that proniosomes are a promising carrier for the transdermal delivery of celecoxib. Thus celecoxib can be formulated into a low dose proniosomal gel that can save the recipient from the adverse effects of large doses.
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Alternate Webpage(s)	http://scienceasia.org/2010.36.n4/scias36_305.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article