Amphiphilic Triblock Copolymers from Poly(2‐oxazoline) with Different Hydrophobic Blocks: Changes of the Micellar Structures upon Addition of a Strongly Hydrophobic Cancer Drug

Content Provider	Semantic Scholar
Author	Jaksch, Sebastian Schulz, Anita Di, Zhenyu Luxenhofer, Robert Jordan, Rainer Papadakis, Christine M.
Copyright Year	2016
Abstract	Amphiphilic triblock copolymers with poly(2-methyl-2-oxazoline) (MeOx) end blocks and a poly(2n -butyl-2-oxazoline) ( n BuOx) middle block have been found to solubilize large amounts of the cancer drug paclitaxel (PTX) whereas this is not the case when the middle block is more hydrophobic, such as poly(2n -nonyl-2-oxazoline) (NOx) (Schulz et al., ACS Nano 2014 , 8 , 2686). To further elucidate the origin of this behavior, dilute aqueous solutions (5–10 mg mL −1 ) of these two copolymers have been investigated by small-angle neutron scattering (SANS), both in the absence and presence of PTX. Whereas PMeOxb -PNOxb -PMeOx forms mainly wormlike micelles coexisting with large aggregates, spherical micelles are predominant in PMeOxb -P n BuOxb -PMeOx. Already small PTX concentrations lead to shape changes in PMeOxb -PNOxb -PMeOx toward spherical micelles. In contrast, changes in the aggregation behavior of PMeOxb -P n BuOxb -PMeOx are only observed at higher PTX concentrations with a transformation into raspberry-like particles, which may explain the high PTX loading capacity of PMeOxb -PnBuOxb -PMeOx micelles.
Starting Page	1448
Ending Page	1456
Page Count	9
File Format	PDF HTM / HTML
DOI	10.1002/macp.201500465
Volume Number	217
Alternate Webpage(s)	https://tu-dresden.de/mn/chemie/mc/mc1/ressourcen/dateien/publikationen/download/2016/Jaksch16.pdf?lang=en
Alternate Webpage(s)	https://doi.org/10.1002/macp.201500465
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article