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Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP): Report of an Institutional Experience with 86 Cases
| Content Provider | Semantic Scholar |
|---|---|
| Author | Pusztaszeri, Marc P. Triponez, Frédéric Meyer, Patrick Sadowski, Samira M. |
| Copyright Year | 2017 |
| Abstract | Background : It was recently proposed that noninvasive follicular variant of papillary thyroid carcinomas (PTCs) should be reclassified as “noninvasive follicular thyroid neoplasm with papillary-like nuclear features†(NIFTP) and treated conservatively. As this is a recent definition, limited data exist about NIFTP. The objective of this study was to report our institutional experience with NIFTP. Materials and Methods : Retrospective study from 2005 to 2015 of all patients with PTCs meeting the histological criteria to be reclassified as NIFTP. We collected information regarding patient demographics, clinical presentation, ultrasound, FNA results, nodule size, multifocality, pathological stage, type and extent of surgery, radioactive iodine treatment, lymph node and systemic metastases, and follow-up. Results : Eighty-six patients (67 women and 19 men, aged 17-83 years (median: 49.5 years)) with NIFTP (median size: 2.5 cm; range: 1.0-5.5 cm) were identified, representing 13.8% of all cases formerly diagnosed as PTC. NIFTP frequently exhibited indeterminate FNA results (71.4%, including suspicious for malignancy (42.9%), follicular neoplasm (20.6%), and AUS/FLUS (7.9%)), while benign (11.3%) and malignant (6.3%) results were less common. Treatment consisted of total thyroidectomy ( n = 42), staged total thyroidectomy ( n = 33) or lobectomy ( n = 11), combined with prophylactic cervical lymph node dissection ( n = 14; all pN0) and post-operative radioactive iodine with 30 mCi ( n = 34) or 100 mCi ( n = 28). All patients were without evidence of disease after a median follow-up of 3.1 years (range 1-11 years). Conclusions : NIFTP represents a significant fraction of cases previously diagnosed histologically as PTC. They were typically diagnosed cytologically as indeterminate and managed like PTCs. None of our patients developed metastases or recurrences. The new NIFTP terminology will have significant impact on the management of patients at our Center. |
| File Format | PDF HTM / HTML |
| Volume Number | 6 |
| Alternate Webpage(s) | http://sspublications.org/index.php/JBCM/article/download/101/79 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
