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Conformational studies of free and Li+ complexed jasplakinolide, a cyclic depsipeptide from the Fijian marine sponge Jaspis splendens.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Tabudravu, Jioji N. Morris, Linda A. Milne, Bruce F. Jaspars, Marcel |
| Copyright Year | 2005 |
| Abstract | The complexation of Li+ to jasplakinolide, a marine sponge derived cyclic depsipeptide showed preferential binding to two out of four carbonyl oxygens (C-10, C-14) and the electrons of the aromatic system of the beta-tyrosine amino acid residue. This is in contrast to previous results obtained by others who proposed complexation to three out of four available carbonyl oxygens (C-1, C-10, C-14). The structure of the complex in CD3CN was determined by NOE restrained molecular dynamic calculations. Structures of the uncomplexed jasplakinolide were calculated in CDCl3 and CD3CN for comparison. |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/B416839A |
| Alternate Webpage(s) | http://www.rsc.org/suppdata/ob/b4/b416839a/b416839a.pdf |
| PubMed reference number | 15731859 |
| Alternate Webpage(s) | https://doi.org/10.1039/B416839A |
| Journal | Medline |
| Volume Number | 3 |
| Issue Number | 5 |
| Journal | Organic & biomolecular chemistry |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
