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Approche multidisciplinaire pour l’amélioration de l’estimation de l’exposition aux sous-produits de désinfection de l’eau en milieu domestique et en piscine
| Content Provider | Semantic Scholar |
|---|---|
| Author | Catto, Cyril |
| Copyright Year | 2012 |
| Abstract | Disinfection of drinking and swimming pool waters disinfection is unavoidable but induces the formation of by-products (DBPs), such as trihalomethanes (THMs), haloacetic acids (HAAs) and chloramines (CAMs), that could be harmful to human health. The still challenging DBP exposure assessment prevent their suspected adverse effects (i.e., cancers, adverse pregnancy outcomes, irritations) to be clearly established. A methodology has been conceptualized which consists of integrating environmental occurrence data with physiologically based toxicokinetic (PBTK) modeling to improve DBP exposure assessment. It was designed to allow both spatial and temporal variations of the environmental contamination and the biological impacts of betweenand withinindividual differences to be accounted for. This thesis comprised of two parts. Each one investigates successively both environmental and biological aspects. The objective is to contribute to the development of an innovative integrated strategy and to the definition of best practices for DBP exposure assessment. The first part of the thesis, comprising papers I and II, focuses on household exposure (i.e., resulting from drinking water use at home) and on THMs, the most abundant and volatile DBPs that can be absorbed not only by ingestion but also by inhalation and dermal absorption. These two papers investigate particularly the short-term (day-to-day and within-day) variations of THM levels in the drinking water and then their impact on the internal exposure indicators. They described the amplitudes and the diversity of the environmental variations, failed to model them in a systematic and practical way for epidemiological purposes but assessed, for the first time, their impacts on the predicted biological levels which appeared quite low. The second part concerns the exposure to DBPs in swimming pool which is of a growing international interest. Only the allegedly worrying case of public indoor swimming pool was regarded. This section focuses on the feasibility of using the previously mentioned approach, which was first designed for dealing with household exposure, for DBP exposure assessment in swimming pools. First, Paper III investigated the occurrence and spatial and temporal variations of DBPs in both water and air of swimming pools to |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://papyrus.bib.umontreal.ca/xmlui/bitstream/handle/1866/8820/Catto_Cyril_2012_these.pdf?isAllowed=y&sequence=3 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
