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Influence of indomethacin on the systemic and pulmonary vascular resistance in man.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Wennmalm, Ake |
| Copyright Year | 1978 |
| Abstract | 1. Indomethacin, an inhibitor of the cyclo-oxygenase system that converts arachidonic acid into prostaglandins and related substances, was infused intravenously in 12 healthy volunteer subjects. 2. Systemic systolic and diastolic blood pressures and heart rate were recorded in all subjects, and in most of them also the systemic arteriovenous oxygen difference, the total oxygen uptake and the pulmonary arterial and wedge pressures. 3. The infusion of indomethacin was followed by a decreased cardiac output (from 7.3 +/- 0.3 to 6.3 +/- 0.3 litres/min) and an increased mean systemic blood pressure (from 92 +/- 1 to 102 +/- 1 mmHg), indicating an elevation of the total systemic vascular resistance (from 98 +/- 4 to 124 +/- 5 kPa 1(-1) s) by indomethacin. The ventilation and the pulmonary vascular resistance did not change after the infusion of indomethacin. 4. The results suggest that products formed by the cyclo-oxygenase system at rest exert a relaxing effect in certain parts of the systemic vascular bed, thereby lowering the systemic vascular resistance. |
| Starting Page | 38 |
| Ending Page | 44 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.clinsci.org/content/ppclinsci/54/2/141.full.pdf |
| PubMed reference number | 413688v1 |
| Volume Number | 54 |
| Issue Number | 2 |
| Journal | Clinical science and molecular medicine |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Arachidonic Acid Burnett Schwartz Berberian syndrome Cardiac Output Diastole Indomethacin Oxygen Peripheral Vascular Diseases Prostaglandin-Endoperoxide Synthase Prostaglandins Respiration Total Peripheral Resistance physical hard work substance torr |
| Content Type | Text |
| Resource Type | Article |
