NDLI: LINGO1 is a regulatory subunit of large conductance, Ca2+-activated potassium channels

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LINGO1 is a regulatory subunit of large conductance, Ca2+-activated potassium channels

Content Provider	Semantic Scholar
Author	Srikanth Dudem Large, Roddy J. Kulkarni, Shruti R. Mcclafferty, H. H. Tikhonova, Irina G. Sergeant, Gerard P. Thornbury, Keith D. Shipston, Michael J. Perrino, Brian A. Hollywood, Mark A.
Copyright Year	2020
Abstract	LINGO1 is a transmembrane protein that is up-regulated in the cerebellum of patients with Parkinson's disease (PD) and Essential Tremor (ET). Patients with additional copies of the LINGO1 gene also present with tremor. Pharmacological or genetic ablation of large conductance Ca2+-activated K+ (BK) channels also result in tremor and motor disorders. We hypothesized that LINGO1 is a regulatory BK channel subunit. We show that 1) LINGO1 coimmunoprecipitated with BK channels in human brain, 2) coexpression of LINGO1 and BK channels resulted in rapidly inactivating BK currents, and 3) LINGO1 reduced the membrane surface expression of BK channels. These results suggest that LINGO1 is a regulator of BK channels, which causes a "functional knockdown" of these currents and may contribute to the tremor associated with increased LINGO1 levels.
Starting Page	2194
Ending Page	2200
Page Count	7
File Format	PDF HTM / HTML
DOI	10.1073/pnas.1916715117
Alternate Webpage(s)	https://pureadmin.qub.ac.uk/ws/portalfiles/portal/198227427/1916715117.full.pdf
Alternate Webpage(s)	https://www.research.ed.ac.uk/portal/files/133430428/2194.full.pdf
PubMed reference number	31932443
Alternate Webpage(s)	https://doi.org/10.1073/pnas.1916715117
Journal	Medline
Volume Number	117
Journal	Proceedings of the National Academy of Sciences of the United States of America
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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