Transcranial direct current stimulation modulates motor responses evoked by repetitive transcranial magnetic stimulation

Content Provider	Semantic Scholar
Author	Cambieri, Chiara Scelzo, Emma Voti, Pietro Li Priori, Alberto Inghilleri, Maurizio
Copyright Year	2012
Abstract	INTRODUCTION Repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) are non-invasive techniques able to induce changes in corticospinal excitability. In this study, we combined rTMS and tDCS to understand possible interactions between the two techniques, and investigate whether they are polarity dependent. MATERIALS AND METHODS Eleven healthy subjects participated in the study. Each patient underwent both anodal and cathodal conditioning tDCS in two separate sessions; brief 5 Hz-rTMS trains were delivered over the primary motor cortex at an intensity of 120% the resting motor threshold (RMT) before tDCS (T0), immediately after (T1) and 10 min after current offset (T2). We then analysed changes induced by cathodal and anodal tDCS on TMS variables. RESULTS Our results showed that in both anodal and cathodal sessions, the motor evoked potential (MEP) amplitude increased significantly in size before stimulation (T0). Conversely, after anodal tDCS, the MEP facilitation measured at T1 and T2 was absent, whereas after cathodal tDCS it was preserved. CONCLUSIONS Our findings provide new direct neurophysiological evidence that tDCS influences primary motor cortex excitability.
Starting Page	167
Ending Page	171
Page Count	5
File Format	PDF HTM / HTML
DOI	10.1016/j.neulet.2012.06.033
PubMed reference number	22732445
Journal	Medline
Volume Number	522
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0304394012008415
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0304394012008415?dgcid=api_sd_search-api-endpoint
Journal	Neuroscience Letters
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article