Loading...
Please wait, while we are loading the content...
Similar Documents
Nano-Structure Analysis of Sugar Chains by Small Angle X-ray Scattering 小角 X 線散乱法による糖鎖分子ナノ構造の解析
| Content Provider | Semantic Scholar |
|---|---|
| Author | Yuguchi |
| Copyright Year | 2009 |
| Abstract | This review describes examples of the structural characterization of sugar chains in solutions or gels at the nano level using small-angle X-ray scattering (SAXS). The review initially focuses on carrageenan, a sulfate-containing electrolytic polysaccharide, aqueous solutions of which undergo gelation when cooled. The gelation process is based on the formation of double helix structures as crosslinking regions. The association state of the various sugar chains can be determined by SAXS. On the basis of SAXS results, it was demonstrated that a 3z solution of k-carrageenan, with potassium ion as the counter cation, yields gels by initial double helix formation and the subsequent association of 2 double helices. In contrast, the gelation of i-carrageenan, which contains a greater number of sulfate groups, was due solely to the formation of double helices. In the second example, the SAXS observation on the structural association between regioselectively desulfated heparin and ˆbroblast growth factor (FGF) is described. The SAXS results indicated that the sulfate group at the 2-O position in the iduronic acid moiety of heparin was essential for aggregation with FGF. It is suggested that the nature of this structural association in‰uences physiological activity. Finally, the SAXS data from a cyclic sugar chain, which has a characteristic proˆle that diŠers from the linear chain structure, is presented, and its inclusion structure is described. A. Introduction Macromolecules composed of sugar molecules are variously termed ``sugar chains,'' ``oligosaccharides,'' ``polysaccharides,'' or ``carbohydrates.'' It is said that these various expressions reveal the diverse nature of sugar chains. These sugar chains play various roles in living organisms, and have been widely exploited in industry. The |
| File Format | PDF HTM / HTML |
| DOI | 10.4052/tigg.21.1 |
| Alternate Webpage(s) | https://www.jstage.jst.go.jp/article/tigg/21/117/21_117_1/_pdf/-char/ja |
| Alternate Webpage(s) | https://doi.org/10.4052/tigg.21.1 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
