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Maternal dietary intake of polyunsaturated fatty acids modifies association between prenatal DDT exposure and child neurodevelopment: A cohort study.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ogaz-González, Rafael Mérida-Ortega, Ángel Torres-Sánchez, Luisa E. Schnaas, Lourdes Hernández-Alcaraz, César Cebrián, Mariano E. Rothenberg, Stephen J. García-Hernández, Rosa María López-Carrillo, Lizbeth |
| Copyright Year | 2018 |
| Abstract | BACKGROUND Maternal 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) serum levels during pregnancy have been negatively linked to child neurodevelopment in contrast to intake of omega-3 and -6 (ω-3 and ω-6) fatty acids. OBJECTIVES To assess whether maternal dietary intake of ω-3 and ω-6 during pregnancy modifies the association between exposure to DDE and child neurodevelopment from age 42-60 months. METHODS Prospective cohort study with 142 mother-child pairs performed in Mexico. DDE serum levels were determined by electron capture gas chromatography. Dietary ω-3 and ω-6 intake was estimated by questionnaire. Child neurodevelopment was assessed by McCarthy Scales. RESULTS Docosahexaenoic (DHA) fatty acid intake significantly modified the association between DDE and motor component: increased maternal DDE was associated with lower motor development in children whose mothers had lower DHA intake (βlog2DDE = -1.25; 95% CI: -2.62, 0.12), in contrast to the non-significant increase among children whose mothers had higher DHA intake (βlog2DDE-motor = 0.50; 95% CI: 0.55, 1.56). Likewise, arachidonic fatty acid (ARA) intake modified the association between DDE and memory component: increased maternal DDE was associated with a significantly larger reduction in the memory component in children whose mothers had lower ARA intake (βlog2DDE = -1.31; 95% CI: -2.29, -0.32) than children whose mothers had higher ARA intake (βlog2DDE-memory = 0.17; 95% CI: -0.78, 1.11). CONCLUSIONS Dietary intake of DHA and ARA during pregnancy may protect against child neurodevelopment damage associated with prenatal maternal DDE levels. |
| Starting Page | 698 |
| Ending Page | 705 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.envpol.2018.03.100 |
| PubMed reference number | 29621729 |
| Journal | Medline |
| Volume Number | 238 |
| Alternate Webpage(s) | http://isiarticles.com/bundles/Article/pre/pdf/154600.pdf |
| Journal | Environmental pollution |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
