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Drug-eluting Stents in Acute Coronary Syndrome: Is There a Risk of Stent Thrombosis with Second-Generation Stents?
| Content Provider | Semantic Scholar |
|---|---|
| Author | Chitkara, Kamal Pujara, Kushal |
| Copyright Year | 2010 |
| Abstract | Over the past decade, the advent of drug-eluting stents (DES) has revolutionised the field of interventional cardiology by having a major impact on patient care through their efficacy in reducing the need for repeat revascularisation. A number of stents capable of delivering an anti-proliferative agent designed to prevent neointimal hyperplasia, the principal mechanism of restenosis after stenting, have been evaluated; four of these devices are currently approved by the U.S. Food and Drug Administration (FDA). Bare metal stent (BMS) and first-generation DES, such as sirolimus-eluting (SES-Cypher(®)) and paclitaxel-eluting stents (PES-Taxus(®)), have further improved results of percutaneous coronary intervention (PCI) by improving early results and reducing the risk of restenosis. However, there is currently debate on the safety of these first-generation DES, given the potential for late stent thrombosis (LST), especially after discontinuation of dual anti-platelet therapy. Second-generation DES, such as zotarolimus-eluting (ZES-Endeavor(®)) and everolimus-eluting stents (EES-Xience V(®)), are become available in the USA and/or Europe. Recently, long-term results comparing DES with BMS in patients with ST-segment-elevation MI (STEMI) have raised some questions about the long-term risks of the drug-eluting devices. It may be useful to pause, reflect for a moment, and consider some recent pertinent results regarding their wider use. This systematic review tries to provide a concise and critical appraisal of the data available to compare first and second generation stents especially to assess risk of stent thrombosis (ST) with second-generation DES. |
| Starting Page | 20 |
| Ending Page | 24 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.healthcare-bulletin.com/uploads/media/Drug-eluting_Stents_in_Acute_Coronary_Syndrome_01.pdf |
| PubMed reference number | 21766004v1 |
| Volume Number | 1 |
| Issue Number | 2 |
| Journal | The European journal of cardiovascular medicine |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Bare Metal Stent CAPOS syndrome Cardiology discipline Drug-Eluting Stents Dual Interventional procedure Large-Scale State Transition Paclitaxel Patients Percutaneous Coronary Intervention Platelet Count measurement Sirolimus Stent Thrombosis Stent, device Taxus United States Food and Drug Administration everolimus restenosis revascularization zotarolimus |
| Content Type | Text |
| Resource Type | Article |
