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There is more to salt than just a pinch of sodium.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Gąsowski, Jerzy Cwynar, Marcin |
| Copyright Year | 2013 |
| Abstract | See related article, pp 836–843 Much of what human life is about is water (60% of body mass) and a handful of solutes. Of the latter, main cations include sodium, potassium, calcium, and magnesium, and the anions include chloride, bicarbonate, phosphate and organic anions, and proteins. The concentrations of sodium (135–145 mmol/L) and chloride (95–106 mmol/L) predominate in serum and constitute the bulk of serum’s osmolarity. In the course of evolution, complex regulatory mechanisms developed to keep the osmolarity (≈280 mosm/L) and thus amount of water at desired level. With it came the role of main solutes and their regulatory mechanisms (ie, renin–angiotensin–aldosterone system [RAAS]) in the regulation of blood pressure. Numerous studies demonstrated the role of sodium-based mechanisms in water homeostasis and blood pressure regulation. Recently, several well-designed studies showed that the level of ingested sodium correlated with the level of blood pressure or cardiovascular risk, and that the relationship is likely to assume a J-curve shape in population of patients with cardiovascular involvement or diabetes mellitus.1 However, experimental studies performed over several decades pointed to the possibility that the form of ingested or infused sodium is of importance. Both in animal models and in human studies, Kurtz and Morris2 and then Luft et al3 were among those who showed that blood pressure elevated when sodium chloride was ingested or infused, but not when the salt used was sodium bicarbonate or sodium citrate. These and other similar studies led to the consideration of chloride as a possible factor in the regulation of blood pressure. Paradoxically, different picture arose when researchers related … |
| File Format | PDF HTM / HTML |
| DOI | 10.1161/HYPERTENSIONAHA.113.01918 |
| Alternate Webpage(s) | http://hyper.ahajournals.org/content/hypertensionaha/62/5/829.full.pdf?download=true |
| PubMed reference number | 23980071 |
| Alternate Webpage(s) | https://doi.org/10.1161/HYPERTENSIONAHA.113.01918 |
| Journal | Medline |
| Volume Number | 62 |
| Issue Number | 5 |
| Journal | Hypertension |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
