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Impaired alveolization in mice deficient in membrane-type matrix metalloproteinase 1 (MT1-MMP)
| Content Provider | Semantic Scholar |
|---|---|
| Author | Irie, Kazuharu Komori, Kiyoshi Seiki, Motoharu Tsuruga, Eichi Sakakura, Yasunori Kaku, Tohru Yajima, Toshihiko |
| Copyright Year | 2004 |
| Abstract | To clarify the involvement of membrane-type matrix metalloproteinase 1 (MT1-MMP) in lung organogenesis, we studied the lung morphology of 13-day-old MT1-MMP null mice. The lung architecture in MT1-MMP null mice was abnormal, and the airspace compartments were characterized by smooth walls and larger size. Most of the compartment wall consisted of one or two layers of cells and interstitial connective tissue that was thicker than that of normal alveoli. The wall frequently had capillaries on both sides of the interstitial connective tissue. These findings indicate that the lung in MT1-MMP null mice at 13 days of age is comparable to that of neonatal mice, i.e., it represents the stage before alveolization, suggesting that the generation of a large respiratory surface – the final process of lung development – is impaired in MT1-MMP null mice. Moreover, a zymography assay revealed decreased activity of matrix metalloproteinase 2 (MMP-2) in MT1-MMP null mice, suggesting that activation of pro-MMP-2 by MT1-MMP is critical in this process. |
| Starting Page | 43 |
| Ending Page | 46 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.1007/s00795-004-0277-9 |
| PubMed reference number | 16158179 |
| Journal | Medline |
| Volume Number | 38 |
| Alternate Webpage(s) | https://page-one.springer.com/pdf/preview/10.1007/s00795-004-0277-9 |
| Alternate Webpage(s) | https://doi.org/10.1007/s00795-004-0277-9 |
| Journal | Medical Molecular Morphology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
