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Electrical amygdala kindling in alcohol-withdrawal kindled rats.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ulrichsen, Jakob Woldbye, David Madsen, Torsten M. Clemmesen, Lars Haugbol, Steven Olsen, Christian Holkmann Holkmann Laursen, Henning Bolwig, Tom Gert Hemmingsen, Ralf |
| Copyright Year | 1998 |
| Abstract | Repeated alcohol withdrawal has been shown to kindle seizure activity. The purpose of the present investigation was to study electrical amygdala kindling in rats previously exposed to alcohol-withdrawal kindling. In three independent experiments, male Wistar rats were subjected to multiple episodes each consisting of 2 days of severe alcohol intoxication and 5 days of alcohol withdrawal. In the first experiment, the alcohol-withdrawal kindled animals were divided into two groups depending on whether spontaneous alcohol-withdrawal seizures were observed in episodes 10-13. In the second and third experiments, the alcohol-withdrawal kindled animals were compared to a group in which alcohol-withdrawal kindling was prevented by diazepam treatment during the withdrawal reactions in order to discriminate between the effect of withdrawal and intoxication. Electrical kindling was initiated 28-35 days after the last alcohol dose by exposing the animals to daily electrical stimulations of the right amygdala. The results showed that amygdala kindling was facilitated in alcohol-withdrawal kindled animals which showed spontaneous withdrawal seizure activity, compared with animals exposed to multiple episodes of alcohol withdrawal which did not develop withdrawal seizures or with animals exposed to a single episode of alcohol intoxication. When compared to the control group, the alcohol-withdrawal kindled group with seizures also kindled at a faster rate, but the difference did not reach statistical significance and therefore the results must be regarded as preliminary at present. |
| File Format | PDF HTM / HTML |
| DOI | 10.1093/oxfordjournals.alcalc.a008388 |
| Alternate Webpage(s) | http://alcalc.oxfordjournals.org/content/alcalc/33/3/244.full.pdf |
| PubMed reference number | 9632050 |
| Alternate Webpage(s) | https://doi.org/10.1093/oxfordjournals.alcalc.a008388 |
| Volume Number | 33 |
| Issue Number | 3 |
| Journal | Alcohol and alcoholism |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
