NDLI: Divergent evolution in M6P/IGF2R imprinting from the Jurassic to the Quaternary.

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Divergent evolution in M6P/IGF2R imprinting from the Jurassic to the Quaternary.

Content Provider	Semantic Scholar
Author	Killian, James K. Nolan, Catherine S. Wylie, Andrew A. Li, Tiansen Vu, Thanh H. Hoffman, Andrew R. Jirtle, Randy L.
Copyright Year	2001
Abstract	M6P/IGF2R imprinting first appeared approximately 150 million years ago following the divergence of prototherian from therian mammals. Although M6P/IGF2R is clearly imprinted in opossums and rodents, its imprint status in humans remains ambiguous. It is also still unknown if M6P/IGF2R imprinting was an ancestral mammalian epigenotype or if it evolved convergently. We report herein that M6P/IGF2R is imprinted in Artiodactyla, as it is in Rodentia and Marsupialia, but that it is not imprinted in Scandentia, Dermoptera and Primates, including ringtail lemurs and humans. These results are most parsimonious with a single ancestral origin of M6P/IGF2R imprinting followed by a lineage-specific disappearance of M6P/IGF2R imprinting in Euarchonta. The absence of M6P/IGF2R imprinting in extant primates, due to its disappearance from the primate lineage over 75 million years ago, demonstrates that imprinting at this locus does not predispose to human disease. Moreover, the divergent evolution of M6P/IGF2R imprinting predicts that the success of in vitro embryo procedures such as cloning may be species dependent.
Starting Page	271
Ending Page	271
Page Count	1
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.geneimprint.org/media/pdfs/11532981_fulltext.pdf
PubMed reference number	11532981v1
Volume Number	10
Issue Number	17
Journal	Human molecular genetics
Language	English
Access Restriction	Open
Subject Keyword	Bassariscus astutus Didelphidae Embryo IGF2R gene IGF2R protein, human Imprinting (Psychology) Lemurs Mammals Order Scandentia (organism) Primates Rodent Superorder Marsupalia (organism)
Content Type	Text
Resource Type	Article

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