NDLI: CLARITY: ChiLdhood Arthritis Risk Factor Identification STudY. Investigating the role of aberrant DNA methylation in juvenile idiopathic arthritis

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CLARITY: ChiLdhood Arthritis Risk Factor Identification STudY. Investigating the role of aberrant DNA methylation in juvenile idiopathic arthritis

Content Provider	Semantic Scholar
Author	Ellis, Justine A. Chavez, R. A. Gordon, Lavinia Ponsonby, Al Lim, Bock Akikusa, J. Allen, Roger C. Saffery, Richard Craig, Jamie Evan Munro, J.
Copyright Year	2011
Abstract	Background Juvenile Idiopathic Arthritis (JIA) is a complex autoimmune disorder likely to be determined by multiple genetic and environmental factors. Mounting evidence shows that epigenetic variation influences autoimmune disease risk. The most well-studied epigenetic mark is DNA methylation; increased methylation of CpG dinucleotides can reduce gene expression. Nothing is currently known about the role of methylation in JIA. In 2008, we established CLARITY, a JIA Biobank that is collecting biospecimens and extensive information about environment from cases presenting to the Royal Children’s Hospital (RCH), Melbourne, Australia. A control sample of healthy children attending the RCH Day Surgery Unit has also been collected.
Starting Page	P275
Ending Page	P275
Page Count	1
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://ped-rheum.biomedcentral.com/track/pdf/10.1186/1546-0096-9-S1-P275
PubMed reference number	3194641
Volume Number	9
Language	English
Access Restriction	Open
Subject Keyword	Autoimmune Diseases Biobank Clarity Measurement Gene Expression Juvenile arthritis Methylation study of epigenetics
Content Type	Text
Resource Type	Article

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