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Community‐acquired respiratory viruses and co‐infection among patients of Ontario sentinel practices, April 2009 to February 2010
| Content Provider | Semantic Scholar |
|---|---|
| Author | Peci, Adriana Winter, Anne‐ Luise Gubbay, Jonathan B. Skowronski, Danuta M. Balogun, Elizabeth I. Lima, C. P. Francis De Crowcroft, Natasha Sarah Rebbapragada, Anuradha |
| Copyright Year | 2013 |
| Abstract | BACKGROUND Respiratory viruses are known to cocirculate but this has not been described in detail during an influenza pandemic. OBJECTIVES To describe respiratory viruses, including co-infection and associated attributes such as age, sex or comorbidity, in patients presenting with influenza-like illness to a community sentinel network, during the pandemic A(H1N1)pdm09 in Ontario, Canada. METHODS Respiratory samples and epidemiologic details were collected from 1018 patients with influenza-like illness as part of respiratory virus surveillance and a multiprovincial case-control study of influenza vaccine effectiveness. RESULTS At least one virus was detected in 668 (65·6%) of 1018 samples; 512 (50·3%) had single infections and 156 (15·3%) co-infections. Of single infections, the most common viruses were influenza A in 304 (59·4%) samples of which 275 (90·5%) were influenza A(H1N1)pdm09, and enterovirus/rhinovirus in 149 (29·1%) samples. The most common co-infections were influenza A and respiratory syncytial virus B, and influenza A and enterovirus/rhinovirus. In multinomial logistic regression analyses adjusted for age, sex, comorbidity, and timeliness of sample collection, single infection was less often detected in the elderly and co-infection more often in patients <30 years of age. Co-infection, but not single infection, was more likely detected in patients who had a sample collected within 2 days of symptom onset as compared to 3-7 days. CONCLUSIONS Respiratory viral co-infections are commonly detected when using molecular techniques. Early sample collection increases likelihood of detection of co-infection. Further studies are needed to better understand the clinical significance of viral co-infection. |
| Starting Page | 559 |
| Ending Page | 566 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 22883216v1 |
| Alternate Webpage(s) | https://doi.org/10.1111/j.1750-2659.2012.00418.x |
| DOI | 10.1111/j.1750-2659.2012.00418.x |
| Journal | Influenza and other respiratory viruses |
| Volume Number | 7 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Coinfection Enterovirus Infections Epidemiology Eye Infections, Viral HIV Infections Herpesvirus 1, Cercopithecine Infection Patients Regression Analysis Respiratory Tract Infections Respiratory syncytial virus Rhinovirus Specimen Collection respiratory virus |
| Content Type | Text |
| Resource Type | Article |
