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Tryptase concentrations in bronchoalveolar lavage from patients with chronic eosinophilic pneumonia.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Bargagli, Elena Bigliazzi, Caterina Leonini, Alessandra Nikiforakis, Nikolaos Perari, Maria Grazia Rottoli, Paola |
| Copyright Year | 2005 |
| Abstract | In order to characterize BAL (bronchoalveolar lavage) in CEP (chronic eosinophilic pneumonia) and to investigate the possible role of mast cells and tryptase in the pathogenesis of this interstitial disease, cells and tryptase levels were determined in BAL of patients with CEP and in a group of healthy controls. The results show that a statistically significant increase in tryptase concentration was found in patients with CEP compared with the healthy controls. This is the first report that shows an increase in tryptase levels in CEP and could reflect higher mast cell activation as well as larger mast cell populations in the lungs of these patients. These results strongly support the involvement of mast cells and eosinophils in the immunopathogenesis of CEP. |
| File Format | PDF HTM / HTML |
| DOI | 10.1042/CS20040178 |
| Alternate Webpage(s) | http://www.clinsci.org/content/ppclinsci/108/3/273.full.pdf |
| PubMed reference number | 15537394 |
| Alternate Webpage(s) | https://doi.org/10.1042/CS20040178 |
| Journal | Medline |
| Volume Number | 108 |
| Issue Number | 3 |
| Journal | Clinical science |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |