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Chiral squaramide-catalysed one-pot enantioselective sulfa-Michael addition/thioesterification of thiols with α,β-unsaturated N-acylated succinimides.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zhao, Bo-Liang Du, Da-Ming |
| Copyright Year | 2014 |
| Abstract | A novel highly enantioselective one-pot dithiolation through sulfa-Michael addition/thioesterification of thiols with α,β-unsaturated N-acylated succinimides catalysed by squaramide has been developed. This organocatalysed reaction proceeded well in high to excellent yields (up to >99%) to afford useful bioactive β-sulfated thioester derivatives with high enantioselectivities (up to 96% ee). |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/c3ob42137f |
| PubMed reference number | 24457948 |
| Journal | Medline |
| Volume Number | 12 |
| Issue Number | 10 |
| Alternate Webpage(s) | http://www.rsc.org/suppdata/ob/c3/c3ob42137f/c3ob42137f.pdf |
| Alternate Webpage(s) | https://doi.org/10.1039/c3ob42137f |
| Journal | Organic & biomolecular chemistry |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |