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The tumor suppressor miR-138-5p targets PD-L1 in colorectal cancer
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zhao, Lian Yu, Haibo Yi, Shuijing Peng, Xiaowei Su, Peng Xiao, Zhiming Liu, Rui Jie Tang, Anliu Li, Xiayu Liu, Fen Lin Shen, Shourong |
| Copyright Year | 2016 |
| Abstract | microRNAs (miRNAs) play critical roles in cancer development and progression. This study investigated the effects of miR-138-5p in human colorectal cancer (CRC) development. miR-138-5p was frequently downregulated in CRC tissues and was associated with advanced clinical stage, lymph node metastasis and poor overall survival. We found that miR-138-5p decreased expression of programmed cell death ligand 1 (PD-L1) through interaction with its PD-L1 3' untranslated region. miR-138-5p also dramatically suppressed CRC cell growth in vitro and inhibited tumorigenesis in vivo. PD-L1 and miR-138-5p levels were inversely correlated in human CRC tumors, and miR-138-5p inhibited PD-L1 expression in tumor models. These results suggest that miR-138-5p is a tumor suppressor in CRC, and its effects are exerted at least partially through PD-L1 downregulation. Low miR-138-5p and high PD-L1 levels correlated with shorter overall CRC patient survival, indicating that miR-138-5p and PD-L1 may serve as CRC biomarkers for risk group assignment, optimal therapy selection and clinical outcome prediction. Targeting PD-L1, possibly by administering miR-138-5p mimics, might be a clinically effective anti-CRC therapeutic strategy. |
| Starting Page | 45370 |
| Ending Page | 45384 |
| Page Count | 15 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.oncotarget.com/index.php?journal=oncotarget&op=download&page=article&path%5B%5D=9659&path%5B%5D=31180 |
| PubMed reference number | 27248318v1 |
| Alternate Webpage(s) | https://doi.org/10.18632/oncotarget.9659 |
| DOI | 10.18632/oncotarget.9659 |
| Journal | Oncotarget |
| Volume Number | 7 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | 3' Untranslated Regions Administration procedure Anatomic Node Apoptosis Biological Markers Body tissue CD274 protein, human Carcinogenesis Cell Death Chromosome 5 Short Arm Colorectal Carcinoma Down-Regulation Forecast of outcome L1 childhood acute lymphoblastic leukemia Ligands Maxillary right first premolar prosthesis MicroRNAs Neoplasms Parkinson Disease Patients Pineal Gland Neoplasm Stage IV Ovarian Carcinoma Tumor Suppressor Genes lymph node metastases lymph nodes physical hard work |
| Content Type | Text |
| Resource Type | Article |
