Dopamine D2 receptor promoter polymorphism: no association with schizophrenia

Content Provider	Semantic Scholar
Author	Tallerico, Teresa Ulpian, Carla
Copyright Year	1999
Abstract	A functional polymorphism in the promoter region of the dopamine D2 receptor gene, the -141C Del allele, which may be associated with schizophrenia susceptibility, has previously been described in a Japanese sample. The present study was done in order to examine whether such an association would also be found in a North American schizophrenia patient population. However, analysis of the -141C Del allele frequency in the present group of schizophrenia patients (n = 50) and control subjects (n = 51) did not identify any significant differences. These data support the recent reports on German and British subjects that this genetic variation in the 5'-flanking region of the dopamine D2 receptor gene does not play a major role in the genetic predisposition to schizophrenia.
Starting Page	215
Ending Page	219
Page Count	5
File Format	PDF HTM / HTML
DOI	10.1016/S0165-1781(98)00125-5
PubMed reference number	10220012
Journal	Medline
Volume Number	85
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0165178198001255
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0165178198001255?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/S0165-1781%2898%2900125-5
Journal	Psychiatry Research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article