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Reactions of 1,2,4-Triazines with Nucleophiles. Part 6. Use of SnH Methodology for the Direct Introduction of Cyclic Diketone Residue into the 1,2,4-Triazine Ring.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kozhevnikov, Dmitry N. Kovalev, Igor S. Rusinov, Vladimir L. Chupakhin, Oleg N. |
| Copyright Year | 2010 |
| Abstract | 3-R-6-Phenyl-1,2,4-triazine 4-oxides react with cyclic β-diketones (dimethylbarbituric acid, dimedone, and indan) in both acidic (substrate activation) and basic conditions (nucleophile activation) with formation of σ-adducts, intermediates in the nucleophilic substitution of hydrogen (SN) in 3-R-5-Nu-4hydroxy-6-phenyl-4,5-dihydro-1,2,4-triazines. Oxidative aromatisation of these intermediates or autoaromatisation of acylated (benzoyl chloride) at the NOH σ-adducts with elimination of benzoic acid gave the corresponding substituted 1,2,4-triazine 4-oxides or 1,2,4-triazines. |
| Starting Page | 1136 |
| Ending Page | 1140 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1002/chin.200232153 |
| Volume Number | 33 |
| Alternate Webpage(s) | https://page-one.springer.com/pdf/preview/10.1023/A:1013287918408 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
