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Estimating Negative Effect of Abdominal Obesity on Mildly Decreased Kidney Function Using a Novel Index of Body-Fat Distribution
| Content Provider | Semantic Scholar |
|---|---|
| Author | Oh, Il Hwan Choi, Jong Wook Lee, Chang Hwa Park, Joon Sung |
| Copyright Year | 2017 |
| Abstract | Abdominal obesity is a major risk factor of chronic kidney disease (CKD). Conventional obesity-related indicators, included body mass index (BMI), waist circumference (WC), and conicity index (C-index), have some limitations. We examined the usefulness of trunk/body fat mass ratio (T/Br) to predict negative effect of abnormal fat distribution on excretory kidney function. We analyzed anthropometric, biochemical and densitometric data from a nation-wide, population-based, case-control study (the Korean National Health and Nutrition Examination Survey [KNHANES] IV and V). A total of 11,319 participants were divided into 2 groups according to estimated glomerular filtration rate (eGFR, mL·min⁻¹·1.73 m⁻²) as follows: Group I (n = 7,980), eGFR ≥ 90 and ≤ 120; and group II (n = 3,339), eGFR ≥ 60 and < 90. Linear regression analysis revealed that T/Br was closely related to eGFR (β = -0.3173, P < 0.001), and the correlation remained significant after adjustment for age, gender, BMI, WC, C-index, systolic blood pressure (BP), hemoglobin, and smoking amount (β = -0.0987, P < 0.001). Logistic regression analysis showed that T/Br (odds ratio [OR] = 1.046; 95% confidence interval [CI] = 1.039-1.054) was significantly associated with early decline of kidney function, and adjustment for age, gender, BMI, C-index, systolic BP, hemoglobin, serum glucose level, high-density lipoprotein (HDL)-cholesterol, and smoking amount did not reduce the association (OR = 1.020; 95% CI = 1.007-1.033). T/Br is useful in estimating the negative impact of abdominal obesity on the kidney function. |
| Starting Page | 613 |
| Ending Page | 620 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 28244287v1 |
| Alternate Webpage(s) | https://doi.org/10.3346/jkms.2017.32.4.613 |
| DOI | 10.3346/jkms.2017.32.4.613 |
| Journal | Journal of Korean medical science |
| Volume Number | 32 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Aortic Aneurysm, Abdominal Body mass index Chronic Kidney Diseases Confidence Intervals EGFR protein, human Estimated Fat embolism (disorder) Glomerular Filtration Rate Glucose measurement Lewy Body Disease Linear IgA Bullous Dermatosis Lipoproteins Pediatric Obesity Platelet Glycoprotein 4, human Smoke Treatment - Filtration Waist Circumference serum glucose |
| Content Type | Text |
| Resource Type | Article |
