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Platycodin D and 2″-o-acetyl-polygalacin D2 isolated from Platycodon grandiflorum protect ischemia/reperfusion injury in the gerbil hippocampus
| Content Provider | Semantic Scholar |
|---|---|
| Author | Choi, Jung Hoon Yoo, Ki-Yeon Park, Ok kyu Lee, Choong Hyun Kang, Il-Jun |
| Copyright Year | 2009 |
| Abstract | Platycodi radix is used as a folk remedy for several conditions. In this study, we investigated the neuroprotective effects of five major extracts; deapioplatycoside E (DPE), platycoside E (PE), platyconic acid A (PA), platycodin D (PD) and 2''-o-acetyl-polygalacin D2 (PD2) isolated from the P.radix in the hippocampal CA1 region (CA1) 4 or 10 days after ischemia/reperfusion (I/R). Each extract was administered into gerbils with intraperitoneal injection (5 mg/kg/day) 10 days before ischemic surgery and the gerbils were sacrificed 4 or 10 days after I/R. Fluoro-Jade B (F-J B, a marker for neurodegeneration) positive ((+)) neurons increased significantly in the stratum pyramidale of the CA1 region in the vehicle-treated group after I/R. A similar pattern was observed in the DPE-, PE- and PA-treated groups; however, in the PD- and PD2-treated groups, F-J B(+) neurons were small in number. We also observed that activations of astrocytes and microglia in the CA1 region after I/R were blocked by the PD- and PD2 treatments. In addition, we found that Cu,Zn-superoxide dismutase (SOD1) immunoreactivity in the pyramidal layer of the PD- and PD2-treated groups was similar to that of the sham group and COX-2(+) and NF-kappaB(+) cells were significantly lower in the PD- and PD2-treated group than those in the vehicle-treated group after I/R. These results suggest that PD and PD2 rescue neurons in the CA1 region from an ischemic damage. |
| Starting Page | 197 |
| Ending Page | 208 |
| Page Count | 12 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.brainres.2009.05.005 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0006899309009329 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0006899309009329?dgcid=api_sd_search-api-endpoint |
| PubMed reference number | 19433075 |
| Alternate Webpage(s) | https://doi.org/10.1016/j.brainres.2009.05.005 |
| Journal | Medline |
| Volume Number | 1279 |
| Journal | Brain Research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
