NDLI: Serotonin but not zonisamide inhibits theophylline-induced epileptiform activity in guinea pig hippocampal CA3 neurons

Content Provider	Semantic Scholar
Author	Thöne, Jan Wiemann, Martin
Copyright Year	2007
Abstract	To test the putative serotonin (5-HT)-like effect of zonisamide (ZNS) we employed xanthine-induced epileptiform activity in the hippocampus slice preparation from guinea pigs. In this model Na(+)- and T-type Ca(2+) channel blockers are hardly effective while 5-HT should be inhibitory. Bath application of 5-HT hyperpolarized neurons and abolished theophylline-induced epileptiform activity. In contrast, ZNS failed to alter epileptiform bursting. We conclude that 5-HT augmenting effects of ZNS are missing or are not sufficient to inhibit epileptiform activity in hippocampal slice preparations.
Starting Page	73
Ending Page	76
Page Count	4
File Format	PDF HTM / HTML
DOI	10.1016/j.eplepsyres.2007.05.010
PubMed reference number	17628426
Journal	Medline
Volume Number	76
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0920121107001672
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0920121107001672?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/j.eplepsyres.2007.05.010
Journal	Epilepsy Research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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Serotonin but not zonisamide inhibits theophylline-induced epileptiform activity in guinea pig hippocampal CA3 neurons