Relationships of elevated systemic pentraxin-3 levels with high-risk coronary plaque components and impaired myocardial perfusion after percutaneous coronary intervention in patients with ST-elevation acute myocardial infarction.

Content Provider	Semantic Scholar
Author	Kimura, Shigeki Inagaki, Hiroshi Haraguchi, G. E. Sugiyama, Tomoyo Miyazaki, Toru Hatano, Yu Yoshikawa, Shunji Ashikaga, Takashi Isobe, Mitsuaki
Copyright Year	2014
Abstract	BACKGROUND We aimed to assess the relationships of pentraxin-3 (PTX3) with coronary plaque components and myocardial perfusion after percutaneous coronary intervention (PCI) in order to clarify the mechanisms underlying the prognostic function of PTX3 in ST-elevation acute myocardial infarction (STEMI) patients. METHODS AND RESULTS We enrolled 75 STEMI patients who underwent pre-PCI virtual histology (VH)-intravascular ultrasound. Relationships of the systemic pre-PCI PTX3 level with coronary plaque components and post-PCI myocardial blush grade (MBG) were evaluated. Lesions with elevated pre-PCI PTX3 (median ≥3.79ng/ml) had higher frequencies of VH-derived thin-cap fibroatheroma (65.8% vs. 24.3%, P<0.0001), plaque rupture (63.2% vs. 24.3%, P=0.001), and post-PCI MBG (0-1) (65.8% vs. 40.5%, P=0.03) than those with PTX3 <3.79ng/ml. In multivariate analysis, pre-PCI PTX3 level was independently related to post-PCI MBG (0-1) (odds ratio, 11.385; 95% confidence interval (CI), 1.346-96.289; P=0.026). At 9-month follow-up, cardiac event-free survival was poorer for patients with post-PCI MBG (0-1) (log-rank test χ(2)=8.6; P=0.003). Cox proportional-hazards analysis showed post-PCI MBG (0-1) (hazard ratio, 4.109; 95% CI, 1.372-12.309; P=0.012) and Killip class >2 on admission (hazard ratio, 5.356; 95% CI, 1.409-20.359; P=0.014) as independent predictors of adverse cardiac events during follow-up. CONCLUSIONS Systemic pre-PCI PTX3 was associated with high-risk plaque components and impaired post-PCI myocardial perfusion. Thus, PTX3 may be a reliable predictor of outcome in STEMI patients.
Starting Page	1
Ending Page	3
Page Count	3
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.jstage.jst.go.jp/article/circj/78/1/78_CJ-13-0329/_pdf
PubMed reference number	24132243v1
Volume Number	78
Issue Number	1
Journal	Circulation journal : official journal of the Japanese Circulation Society
Language	English
Access Restriction	Open
Subject Keyword	Confidence Intervals Dental Plaque Disease-Free Survival Fibroatheroma Hazard Ratio Myocardium PITX3 gene PTX3 gene PTX3 protein, human Patients Percutaneous Coronary Intervention Rupture ST segment elevation myocardial infarction Senile Plaques
Content Type	Text
Resource Type	Article