NDLI: Immunization with HIV-1 gp41 subunit virosomes induces mucosal antibodies protecting nonhuman primates against vaginal SHIV challenges.

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Immunization with HIV-1 gp41 subunit virosomes induces mucosal antibodies protecting nonhuman primates against vaginal SHIV challenges.

Content Provider	Semantic Scholar
Author	Bomsel, Morgane Tudor, Daniela Ioana Drillet, A. Alfsen, Annette Ganor, Yonatan Roger, M. Mouz, Nicolas Amacker, Mario Chalifour, Anick Diomede, Lorenzo Devillier, Gilles Cong, Zhe Wei, Qiang Qin, Chuan Yang, Gui-Bo Zurbriggen, Rinaldo Lopalco, Lucia Fleury, Sylvain
Copyright Year	2011
Abstract	Human immunodeficiency virus (HIV)-1 is mainly transmitted mucosally during sexual intercourse. We therefore evaluated the protective efficacy of a vaccine active at mucosal sites. Macaca mulatta monkeys were immunized via both the intramuscular and intranasal routes with an HIV-1 vaccine made of gp41-subunit antigens grafted on virosomes, a safe delivery carrier approved in humans with self-adjuvant properties. Six months after 13 vaginal challenges with simian-HIV (SHIV)-SF162P3, four out of five vaccinated animals remained virus-negative, and the fifth was only transiently infected. None of the five animals seroconverted to p27gag-SIV. In contrast, all 6 placebo-vaccinated animals became infected and seroconverted. All protected animals showed gp41-specific vaginal IgAs with HIV-1 transcytosis-blocking properties and vaginal IgGs with neutralizing and/or antibody-dependent cellular-cytotoxicity activities. In contrast, plasma IgGs totally lacked virus-neutralizing activity. The protection observed challenges the paradigm whereby circulating antiviral antibodies are required for protection against HIV-1 infection and may serve in designing a human vaccine against HIV-1-AIDS.
File Format	PDF HTM / HTML
DOI	10.1016/j.immuni.2011.01.015
PubMed reference number	21315623
Journal	Medline
Volume Number	34
Issue Number	2
Alternate Webpage(s)	http://www.assim.refer.org/raisil/page88/page98/files/page98-virosome-hiv.pdf
Alternate Webpage(s)	http://files.chuv.ch/internet-docs/ial/ial-article-bomsel_immunity-2011.pdf
Alternate Webpage(s)	https://doi.org/10.1016/j.immuni.2011.01.015
Journal	Immunity
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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