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Oral treatment with a glucosamine-chondroitin sulfate compound for degenerative joint disease in horses: 25 cases
| Content Provider | Semantic Scholar |
|---|---|
| Author | Hanson, Russell Reid Smalley, L. R. Huff, Gerald K. White, S. Hammad, Tarek A. |
| Copyright Year | 1997 |
| Abstract | Tarek A. Hammad, MD, PhD, Msc, MS Department of Epidemiology University of Maryland School of Medicine Baltimore, Maryland 21 201 D egenerative joint disease (Dl and its associated joint pathorogy contributes significantly to musculoskeletal lameness and loss of function in athletic and pleasure Cartilage is made up of collagen fibers, glycosaminoglycans (GAG), and proteoglycans in a predominately water m a t r i ~ . ~ , ~ A decrease in GAG content in osteoarthritic cartilage is associated in direct proportion with the severity of the disea~e.~-~ With a loss of GAG content the articular cartilage loses its elasticity and ability to bear and transmit forces efficiently, thus resulting in a cascading cycle of more cartilage insults.' This complex process results in the net loss of cartilage and eventual death of the chondrocy te~ .~ Traditional treatment of DJD has centered around non steroidal anti-inflammatory drugs (NSAIDs) and steroidal therap ie~ .~ The chronic use of many of these agents can decrease or suppress chondrocyte metabolism and cause further degradation of the cartilage matrix by the inhibition of normal collagen and proteoglycans synthesis. Some NSAlDs can cause gastrointestinal ulceration and hemorrhage.g,10 The problems and limitations of NSAlDs and steroidal anti-inflammatory agents have recently led to a search for agents that relieve pain and inflammation and limit or reverse cartilage degeneration side effects.'' C agents have been without hondrop rotective |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.vetmed.auburn.edu/wp-content/uploads/2015/01/27-Oral-treatment-with-a-glucosamine-chondroitin-sulfate-compound-for-degenerative-joint-disease-in-horses-25-cases-Equine-Practice-1997.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
