Loading...
Please wait, while we are loading the content...
Similar Documents
Choosing the right drug to fit the patient when selecting oral anticoagulation for stroke prevention in atrial fibrillation.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Shields, Adrian Matthew Lip, Gregory Y. H. |
| Copyright Year | 2015 |
| Abstract | Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide and is a growing health problem that is associated with a significantly increased risk of stroke and thromboembolism. Oral anticoagulant (OAC) therapy reduces the risk of stroke and all-cause mortality in patients with AF. OAC therapy is commonly given as a well-controlled vitamin K antagonist (VKA; e.g. warfarin) and can reduce the risk of stroke in AF patients by almost two-thirds. However, the widespread use of VKAs has been hampered by the unpredictable pharmacokinetic and pharmacodynamic properties of the drugs and justifiable concerns about the consequent risk of haemorrhage. The non-VKA OACs (NOACs) have revolutionized thromboprophylaxis in AF by providing therapeutic options with predictable pharmacodynamic and pharmacokinetic properties that are as efficacious as warfarin in the prevention of stroke and thromboembolism but are more convenient to use. In this review, we provide a patient-centred framework to assist clinicians in recommending the right OAC therapy to fit the individual patient with AF, including methods for stratifying the risk of stroke and haemorrhage and the chances of achieving tight control of VKA anticoagulation, and we discuss the properties of the NOACs that favour their use in particular patient cohorts. |
| Starting Page | 1 |
| Ending Page | 18 |
| Page Count | 18 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://excellence.acforum.org/sites/default/files/Choosing%20a%20DOAC%20in%20AF_Shields_et_al-2015-Journal_of_Internal_Medicine.pdf |
| PubMed reference number | 25758241v1 |
| Alternate Webpage(s) | https://doi.org/10.1111/joim.12360 |
| DOI | 10.1111/joim.12360 |
| Journal | Journal of internal medicine |
| Volume Number | 278 |
| Issue Number | 1 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acquired Immunodeficiency Syndrome Artificial cardiac pacemaker Atrial Fibrillation Cerebrovascular accident Cooley's anemia Decision Support Techniques Editorial Ephrin Type-B Receptor 1, human Heart Atrium Hemorrhage High Risk Acute Leukemia Internal medicine specialty Intracranial Hemorrhages Kidney Diseases N(4)-oleylcytosine arabinoside Nitroglycerin/Sodium Citrate/Ethanol Solution Patients Pharmacodynamics Thromboembolism Ventricular Fibrillation Vitamin K Warfarin benefit oral anticoagulants |
| Content Type | Text |
| Resource Type | Article |
