Loading...
Please wait, while we are loading the content...
Similar Documents
Efficacy of pre-supplementary motor area transcranial direct current stimulation for treatment resistant obsessive compulsive disorder: A randomized, double blinded, sham controlled trial
| Content Provider | Semantic Scholar |
|---|---|
| Author | Gowda, Shayanth Manche Narayanaswamy, Janardhanan C. Hazari, Nandita Bose, Anushree Reddy, Yemmiganur Chandrashekar Janardhan |
| Copyright Year | 2019 |
| Abstract | BACKGROUND A significant proportion of obsessive compulsive disorder (OCD) patients do not respond to specific serotonin reuptake inhibitors (SSRIs). There is a need to evaluate novel treatment options for OCD. OBJECTIVE In this double blinded, randomized, sham controlled study, we investigated the efficacy of add-on transcranial direct current stimulation (tDCS) in reducing the symptoms in SSRI-resistant OCD patients by employing anodal pre-supplementary motor area (pre-SMA) stimulation. METHOD Twenty-five patients with DSM-IV OCD having persistent symptoms despite adequate and stable treatment with at least one SSRI were randomly allocated to receive 20 min of verum (active) 2-mA tDCS or sham stimulation twice daily on 5 consecutive days [anode over Pre-SMA; cathode over right supra-orbital area]. Response to treatment was defined as at least 35% reduction in the Yale-Brown Obsessive-Compulsive Scale (YBOCS) total score along with a Clinical Global Impression - Improvement (CGI-I) score of 1 (very much improved) or 2 (much improved). RESULTS The response rate was significantly greater in the verum tDCS(4 out of 12) compared to sham-tDCS (0 out of 13) [Fisher's exact test, p = 0.04]. Repeated measures analysis of variance with tDCS type (verum vs. sham) as between subjects factor showed that there was a significant tDCS-type X time-point interaction with significantly greater reduction of YBOCS total score [F (1,22) = 4.95,p = 0.04,partial-η2 = 0.18] in verum-tDCS group. CONCLUSIONS The results of this RCT suggest that tDCS may be effective in treating SSRI-resistant OCD. Future studies should examine the efficacy in larger samples of OCD and explore other potential target regions using randomized sham-controlled designs, in addition to examining the sustainability of the beneficial effects. TRIAL REGISTRATION Clinical Trials Registry India (http://ctri.nic.in/Clinicaltrials/login.php): Registration Number- CTRI/2016/04/006837). |
| Starting Page | 922 |
| Ending Page | 929 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.brs.2019.02.005 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S1935861X19300580 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S1935861X19300580?dgcid=api_sd_search-api-endpoint |
| PubMed reference number | 30808612 |
| Alternate Webpage(s) | https://doi.org/10.1016/j.brs.2019.02.005 |
| Journal | Medline |
| Volume Number | 12 |
| Journal | Brain Stimulation |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
