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Quantitative hemodynamic effects of heart rate in aortic regurgitation.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Judge, T. P. Kennedy, Jamie L. W. Bennett, Lee Wills, R. E. Murray, John A. Blackmon, J. R. |
| Copyright Year | 1971 |
| Abstract | The hemodynamic effect of varying heart rate was studied in eight patients with aortic regurgitation. At the subjects' resting sinus rhythm and at a higher heart rate induced with right atrial pacing, left ventricular and aortic pressures and Fick cardiac outputs (FCO) were measured, and left ventricular biplane angiocardiograms were performed. Left ventricular volumes and left ventricular minute flow (LVMF) were determined from the angiograms. Regurgitant flow was quantitated by subtracting the FCO from LVMF. Increased heart rate produced highly significant reductions in the left ventricular end-diastolic pressure (LVEDP), left ventricular end-diastolic volume, and stroke volume. End-diastolic circumferential stress (EDCS) and enddiastolic load (EDL) were abnormally high at resting sinus rhythm and were markedly decreased with increased heart rate. FCO increased, but no significant changes were observed in either the LVMF or the regurgitant flow per minute. Bradyeardia in aortic regurgitation may cause pulmonary congestion secondary to high LVEDP and may accelerate left ventricular dilatation secondary to markedly elevated EDCS and EDL. The possible benefits of preventing bradyeardia in aortic regurgitation by chronic demand pacing is currently being tested. |
| Starting Page | 161101 |
| Ending Page | 161101 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://circ.ahajournals.org/content/circulationaha/44/3/355.full.pdf |
| Alternate Webpage(s) | http://circ.ahajournals.org/content/circulationaha/44/3/355.full.pdf?download=true |
| PubMed reference number | 5097439v1 |
| Volume Number | 44 |
| Issue Number | 3 |
| Journal | Circulation |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Aortic Valve Insufficiency Artificial cardiac pacemaker Cardiac Output Cerebrovascular accident Circumference Diastole Diastolic blood pressure Heart Atrium Hemodynamics Kidney Failure, Chronic Left Ventricular Hypertrophy Patients Regurgitation Rest Sinus - general anatomical term Stroke Volume Tachycardia Ventricular Dysfunction, Left angiogram chest congestion |
| Content Type | Text |
| Resource Type | Article |
