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The metabolism of cis- and trans-decalin.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Elliott, T. H. Robertson, James S. Williams, R. Tecwyn |
| Copyright Year | 1966 |
| Abstract | 1. The metabolism of cis- and trans-decalin in the rabbit has been investigated. 2. Both hydrocarbons were oxidized to racemic secondary alcohols and excreted as ether glucuronides in amounts equal to about 60% of the dose administered. The principal glucuronides were isolated as triacetyl methyl esters and as sodium salts. 3. cis-Decalin gave rise mainly to (+/-)-cis-cis-2-decalol, together with a little cis-trans-2-decalol, and trans-decalin mainly to (+/-)-trans-cis-2-decalol and a small amount of trans-trans-2-decalol. 4. These results suggest that biological oxidation of the decalins does not occur via a free-radical mechanism. An attempt is made to explain why racemic alcohols are obtained, rather than the more typical optically active products of enzymic reaction, and a mechanism is proposed. It is suggested that enzymes similar to steroid hydroxylases are involved. |
| File Format | PDF HTM / HTML |
| DOI | 10.1042/bj1000403 |
| PubMed reference number | 5968538 |
| Journal | Medline |
| Volume Number | 100 |
| Issue Number | 2 |
| Alternate Webpage(s) | http://www.biochemj.org/content/ppbiochemj/100/2/403.full.pdf |
| Alternate Webpage(s) | https://doi.org/10.1042/bj1000403 |
| Journal | The Biochemical journal |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |