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Influence of Cr Adhesion Layer on Detection of Amyloid-Derived Diffusible Ligands Based on Localized Surface Plasmon Resonance
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zhu, Shaoli Du, Chunlei Fu, Yongqi Deng, Q. Shi, Lifang |
| Copyright Year | 2009 |
| Abstract | A Cr adhesion layer inserted between Ag nanoparticles and a glass substrate, for the purpose of improving the adhesion of Ag nanoparticles to glass, was observed to cause an abnormal peak shift of extinction spectra in non-specific reactions. The undesired peak shift misleads molecule detection in non-specific reactions. To solve this issue, a practical technique using n-propyl-trimethoxysilane-based passivation for the detection of amyloid-derived diffusible ligands was investigated as a route to eliminate the abnormal peak shifting observed in the non-specific reactions. To evaluate this passivation technique, localized surface plasmon resonance immunoassay experiments were conducted. Experimental results derived with and without the passivation process were investigated as a basis for comparative analysis. Our experimental results demonstrate that this passivation technique effectively eliminates the observed peak shift originating from the Cr adhesion layer. |
| Starting Page | 135 |
| Ending Page | 140 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.1007/s11468-009-9084-4 |
| Volume Number | 4 |
| Alternate Webpage(s) | https://espace.library.uq.edu.au/data/UQ_235007/UQ235007_fulltext.pdf?Expires=1505033091&Key-Pair-Id=APKAJKNBJ4MJBJNC6NLQ&Signature=bOrd6e~UQ-1lFuaG~uUyZPdQUO-l64B9uzqJizYXL0w~ft4ZSO3aZmzWkQ5I9-HJHGJQ6OgGOmmwhNFWz9WdaixDHCwrLdy8QB-0yXoJMDhEfs24~Td4W2DXPKFITy9G2z~wiyu9Gl7JkB1EnbrfcaYkD3zUxbvgKq1RjEOoQsT-9iphrsXfHqrLLcUj~sspl9EDxMQcMeiiBJnt1GmdYclluT9okR9EcCT5bti9KtmuxOI~e4QUI5tKoNcF611ev-Q128blYe2fQ~taxihatS0B~xRIV0hsSU0sxTyCEPMIYHXiO~wR2pI0GqNRdT~p5PoBGJujn2PUYP3WlE0AcQ__ |
| Alternate Webpage(s) | https://doi.org/10.1007/s11468-009-9084-4 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
