NDLI: Tyrosinase Inhibition, 2,2-diphenyl-1-picrylhydrazyl Radical Scavenging Activity, and Phytochemical Screening of Fractions and Ethanol Extract from Leaves and Stem Bark of Matoa (pometia Pinnata)

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Tyrosinase Inhibition, 2,2-diphenyl-1-picrylhydrazyl Radical Scavenging Activity, and Phytochemical Screening of Fractions and Ethanol Extract from Leaves and Stem Bark of Matoa (pometia Pinnata)

Content Provider	Semantic Scholar
Author	Sauriasari, Rani Azizah, Nur Basah, Katrin
Copyright Year	2017
Abstract	Objective: This study aims to investigate the potency of matoa as a tyrosinase inhibitor and antioxidant and also to identify the chemical compounds in the most active fraction and an ethanol extract from the leaves and stem bark of matoa. Methods: The extracts were tested for their tyrosinase inhibitory activity by evaluating the formation of L-dopachrome at 490 nm. Antioxidant activity was tested using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. The most active extract from liquid-liquid partition analysis was fractionated, and then, the assays were performed. Results: The ethanol extract of leaves and stem bark of matoa showed weak anti-tyrosinase activity (percent inhibition was 24.54±0.22% and 21.93±0.57%, respectively, final concentration 200 μg/mL), but they showed strong DPPH radical scavenging activity (IC50 values were 6.11 μg/mL and 5.47 μg/mL, respectively). The ethyl acetate fraction was the most active fraction with an IC50 value of 5.38 μg/mL. Ethanol extract from the leaves and stem bark of matoa and the ethyl acetate fraction contains flavonoids, tannins, saponins, triterpenoids, and glycosides. Conclusion: Matoa does not have potency as a tyrosinase inhibitor, but it has good antioxidant activity, although still lower than that of quercetin.
Starting Page	85
Ending Page	89
Page Count	5
File Format	PDF HTM / HTML
DOI	10.22159/ajpcr.2017.v10s5.23105
Volume Number	10
Alternate Webpage(s)	https://innovareacademics.in/journals/index.php/ajpcr/article/download/23105/12903
Alternate Webpage(s)	https://doi.org/10.22159/ajpcr.2017.v10s5.23105
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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