Synthesis of methyl [3-alkyl-2-(2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl)-acetamido] alkanoate

Content Provider	Semantic Scholar
Author	Ismail, El Fekki Ali, Ibrahim Ahmed Ibrahim Fathalla, Walid Alsheikh, Amer A. Tamneya, El Said El
Copyright Year	2017
Abstract	A series of methyl [3-alkyl-2-(2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl)-acetamido] alkanoate 10-13a-f has been developed on the basis of the N-chemoselective reaction of 3-substituted quinazoline-2,4-diones 3a-d with ethyl chloroacetate and azide coupling method with amino acid ester hydrochloride. The precursor quinazoline diones 3a-d chemoselective reactions were studied using DFT(B3LYP)/6-311G level of theory and were prepared by a new rearrangement method from the corresponding 2-(3-methyl-4-oxo-3,4dihydroquinazolin-2-ylthio) acetohydrazide 6.
Starting Page	104
Ending Page	120
Page Count	17
File Format	PDF HTM / HTML
DOI	10.24820/ark.5550190.p009.947
Volume Number	2017
Alternate Webpage(s)	https://www.arkat-usa.org/get-file/59999/
Alternate Webpage(s)	https://doi.org/10.24820/ark.5550190.p009.947
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article