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Impact of biofilm matrix components curli fimbriae and cellulose on interaction of commensal Escherichia coli with gastrointestinal cell line HT-29 Running title: interaction of commensal Escherichia coli with HT-29 cell line
| Content Provider | Semantic Scholar |
|---|---|
| Author | Wang, Xiaoda Rochon, Maike Lamprokostopoulou, Agaristi Lünsdorf, Heinrich Nimtz, Manfred Römling, Ute |
| Copyright Year | 2007 |
| Abstract | Commensal Escherichia coli form biofilms at body temperature by expressing the extracellular matrix components curli fimbriae and cellulose. The role of curli fimbriae and cellulose in the interaction of commensal E. coli with the intestinal epithelial cell line HT-29 was investigated. Expression of curli fimbriae by the typical commensal isolate E. coli TOB1 caused adherence and internalization of the bacteria and triggered IL-8 production in HT-29 cells. In particular, induction of IL-8 production was complex and involved curli-bound flagellin. While cellulose alone had no effect on the interaction of TOB1 with HT-29 cells, co-expression of cellulose with curli fimbriae decreased adherence to, internalization and IL-8 induction of HT-29 cells. Investigation of a panel of commensal isolates showed a partial correlation between expression of curli fimbriae and enhanced internalisation and IL-8 production. Thus, the consequences of expression of extracellular matrix components on commensal bacterial-host interactions are complex. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://hzi.openrepository.com/hzi/bitstream/10033/12489/1/R%C3%B6mling.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
