C-reactive protein: ligands, receptors and role in inflammation.

Content Provider	Semantic Scholar
Author	Marnell, Lorraine L. Mold, Carolyn Clos, Terry W. Du
Copyright Year	2005
Abstract	C-reactive protein (CRP) is the prototypical acute phase serum protein, rising rapidly in response to inflammation. CRP binds to phosphocholine (PC) and related molecules on microorganisms and plays an important role in host defense. However, a more important role may be the binding of CRP to PC in damaged membranes. CRP increases clearance of apoptotic cells, binds to nuclear antigens and by masking autoantigens from the immune system or enhancing their clearance, CRP may prevent autoimmunity. CRP binds to both the stimulatory receptors, FcgammaRI and FcgammaRIIa, increasing phagocytosis and the release of inflammatory cytokines; and to the inhibitory receptor, FcgammaRIIb, blocking activating signals. We have shown that, in two animal models of systemic lupus erythematosus (SLE), the (NZB x NZW)F1 mouse and the MRL/lpr mouse, a single injection of CRP before onset of proteinuria delayed disease development and late treatment reversed proteinuria. Thus, in these models, CRP plays an anti-inflammatory role.
Starting Page	293
Ending Page	305
Page Count	13
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://ccfmuc09.files.wordpress.com/2011/10/crp1.pdf
PubMed reference number	16214080v1
Volume Number	117
Issue Number	2
Journal	Clinical immunology
Language	English
Access Restriction	Open
Subject Keyword	Animal Model Anti-Inflammatory Agents Antigens, Nuclear Autoantigens Autoimmune Diseases C-reactive protein Cardiovascular Diseases Complement System Proteins Fc gamma receptor IIA Genetic Polymorphism Hereditary Diseases Immune system Inflammation Ligands Lupus Erythematosus, Systemic Mice, Inbred NZB Microorganism Obesity Phagocytosis Phosphorylcholine Serum Proteins Smoke Tissue membrane Vascular Diseases cytokine host defense vascular inflammations
Content Type	Text
Resource Type	Article