NDLI: An efficient and green method for regio- and chemo-selective Friedel–Crafts acylations using a deep eutectic solvent ([CholineCl][ZnCl2]3)

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An efficient and green method for regio- and chemo-selective Friedel–Crafts acylations using a deep eutectic solvent ([CholineCl][ZnCl2]3)

Content Provider	Semantic Scholar
Author	Tran, Phuong Hoang Nguyen, Hai Truong Hansen, Poul Erik Lê, Thạch Ngọc
Copyright Year	2016
Abstract	[CholineCl][ZnCl2]3, a deep eutectic solvent between choline chloride and ZnCl2, has been used as a dual function catalyst and green solvent for the Friedel–Crafts acylation of aromatic compounds instead of using the moisture-sensitive Lewis acids and volatile organic solvents. The reactions are performed with high yields under microwave irradiation with short reaction times for the synthesis of ketones. Interestingly, indole derivatives are regioselectively acylated in the 3-position under mild conditions with high yields without NH protection. Three new ketone products are synthesized. [CholineCl][ZnCl2]3 is easily synthesized from choline chloride and zinc chloride at a low cost, with easy purification and environmentally benign compounds. [CholineCl][ZnCl2]3 can be reused up to five times without loss of catalytic activity, making it ideal in industrial processes.
Starting Page	37031
Ending Page	37038
Page Count	8
File Format	PDF HTM / HTML
DOI	10.1039/C6RA03551E
Volume Number	6
Alternate Webpage(s)	http://pubs.rsc.org/en/content/articlepdf/2016/ra/c6ra03551e
Alternate Webpage(s)	https://rucforsk.ruc.dk/ws/files/59274074/c6ra03551e.pdf
Alternate Webpage(s)	https://rucforsk.ruc.dk/ws/portalfiles/portal/59274074/c6ra03551e.pdf
Alternate Webpage(s)	https://doi.org/10.1039/C6RA03551E
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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